REVIEWS
Comprehensive Global Review Services
Ensure comprehensive ethics and safety oversight with Advarra’s full suite of ethical review committee services. We provide the governance needed to protect stakeholders, uphold data integrity, and maintain regulatory compliance.
- Institutional Review Board (IRB)
- Institutional Biosafety Committee (IBC)
- Data Monitoring Committee (DMC)
- Endpoint Adjudication Committee (EAC)
Trusted by Top Organizations
Proven Experience
The leader in independent review services for over 40 years overseeing 12,000+ protocols annually. Participant protection is in our DNA.
Trusted Partner
Trusted partner to the top 50 global biopharma sponsors, the top 20 CROs, and 3,500+ institutions, academic medical centers, and hospital systems, including all NCI-Designated Cancer Centers.
Faster Reviews
Unmatched quality and speed of delivery to optimize study startup. Our turnaround times keep your study on track and participants safe.
Single Source for Safety and Compliance Reviews for Every Need
IRBs help ensure the proper protection of clinical trial participants’ rights and welfare. Advarra works with every major U.S.-based sponsor and CRO, and with more institutional sites than any other IRB provider.
Our technology-enabled processes ensure responsive support when you need it, and we lead the industry in quality and efficiency.
IBCs review research involving cell and gene therapy techniques (e.g., engineered genetic material) to ensure the safety of research participants, study staff, and the community in which the study takes place. Even when National Institutes of Health (NIH) support is not involved, IBC review is considered an industry best practice.
Advarra’s IBC has more registered sites than any other IBC, with geographic diversity to support diversity initiatives and seasonal projects.
We provide IBC reviews and biosafety consulting capabilities for clinical, pre-clinical, and nonclinical research worldwide.
An independent DMC satisfies international regulatory requirements for clinical protocols to include an adequate data safety monitoring plan and to provide periodic review of accumulated data during a clinical trial. As a general rule, if the study is blinded, it likely needs DMC oversight.
We have 1,500+ biostatisticians, medical experts, and clinical professionals globally supporting Advarra’s DSMB and EAC. No other independent DMC provider has a larger expert network or provides faster review than Advarra.
Clinical events taking place during a study must be assessed to determine whether the investigational therapy or other outside factors caused them. Researchers may also require specialized medical judgment to determine whether a participant has met a protocol-defined endpoint.
Advarra’s EAC services leverage the largest global network of medical experts, biostatisticians, and other clinical professionals, with 1,500+ experts in every therapeutic area, trial design, and complex endpoint.
Our technology-enabled adjudication services help ensure timely consensus agreements on key clinical events occurring throughout a trial.
Learn How a Leading CRO Accelerated Startup
Advarra’s integrated central IRB and IBC review services helped Parexel accelerate the delivery of life-saving and innovative gene therapies.
NATIVE INTEGRATION
Technology-enabled Reviews
Improve compliance and reduce administrative burden with the most integrated reviews solutions in the industry.
All of our reviews are supported by our best-in-class technology platforms, which provide clients with real-time information on review timelines and deliverables.
Advarra’s reviews technologies integrate easily into a sponsor’s electronic trial master file (eTMF) platforms and site systems via API.
Frequently Asked Questions
Explore our comprehensive FAQ page for detailed answers to questions about our IRB, IBC, DMC, and EAC services.
