REVIEWS

Comprehensive Global Review Services

  • Institutional Review Board (IRB)
  • Institutional Biosafety Committee (IBC)
  • Data Monitoring Committee (DMC)
  • Endpoint Adjudication Committee (EAC)

Trusted by Top Organizations

Proven Experience

The leader in independent review services for over 40 years overseeing 12,000+ protocols annually. Participant protection is in our DNA.

Trusted Partner

Trusted partner to the top 50 global biopharma sponsors, the top 20 CROs, and 3,500+ institutions, academic medical centers, and hospital systems, including all NCI-Designated Cancer Centers.  

Faster Reviews

Unmatched quality and speed of delivery to optimize study startup. Our turnaround times keep your study on track and participants safe.  

Single Source for Safety and Compliance Reviews for Every Need

IRBs help ensure the proper protection of clinical trial participants’ rights and welfare. Advarra works with every major U.S.-based sponsor and CRO, and with more institutional sites than any other IRB provider.   

 Our technology-enabled processes ensure responsive support when you need it, and we lead the industry in quality and efficiency. 

IBCs review research involving cell and gene therapy techniques (e.g., engineered genetic material) to ensure the safety of research participants, study staff, and the community in which the study takes place. Even when National Institutes of Health (NIH) support is not involved, IBC review is considered an industry best practice.   

Advarra’s IBC has more registered sites than any other IBC, with geographic diversity to support diversity initiatives and seasonal projects. 

We provide IBC reviews and biosafety consulting capabilities for clinical, pre-clinical, and nonclinical research worldwide.

An independent DMC satisfies international regulatory requirements for clinical protocols to include an adequate data safety monitoring plan and to provide periodic review of accumulated data during a clinical trial.  As a general rule, if the study is blinded, it likely needs DMC oversight. 

We have 1,500+ biostatisticians, medical experts, and clinical professionals globally supporting Advarra’s DSMB and EAC. No other independent DMC provider has a larger expert network or provides faster review than Advarra.  

Clinical events taking place during a study must be assessed to determine whether the investigational therapy or other outside factors caused them. Researchers may also require specialized medical judgment to determine whether a participant has met a protocol-defined endpoint.  

Advarra’s EAC services leverage the largest global network of medical experts, biostatisticians, and other clinical professionals, with 1,500+ experts in every therapeutic area, trial design, and complex endpoint. 

Our technology-enabled adjudication services help ensure timely consensus agreements on key clinical events occurring throughout a trial.  

Learn How a Leading CRO Accelerated Startup

NATIVE INTEGRATION

Technology-enabled Reviews 

Improve compliance and reduce administrative burden with the most integrated reviews solutions in the industry.  

All of our reviews are supported by our best-in-class technology platforms, which provide clients with real-time information on review timelines and deliverables. 

Advarra’s reviews technologies integrate easily into a sponsor’s electronic trial master file (eTMF) platforms and site systems via API. 

Frequently Asked Questions

Information for Participants and Patient Advocacy Groups

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